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  1. 24 de abr. de 2020 · Nature Communications - Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours,...

    • Chong Zhang, Lin Zhang, Tianlei Xu, Ruidong Xue, Liang Yu, Yuelu Zhu, Yunlong Wu, Qingqing Zhang, Do...
    • 2020
  2. 12 de mar. de 2021 · In this review, we focus on delineating the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes and further spread to other distant organs. In addition, emerging molecular targets and potential strategies to inhibit lymph node metastasis are discussed.

    • Hengbo Zhou, Pin-Ji Lei, Timothy P Padera
    • 10.3390/cells10030627
    • 2021
    • Cells. 2021 Mar; 10(3): 627.
  3. 15 de jul. de 2016 · Colorectal cancer (CRC) is the third most common cancer worldwide 1. Approximately 56% of patients with CRC die from their cancer 2. Development of metastasis is a concern for patients and...

    • Matias Riihimäki, Matias Riihimäki, Akseli Hemminki, Jan Sundquist, Kari Hemminki, Kari Hemminki
    • 2016
  4. Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectalcancer(CRC).Howtumorcellsdisseminatewithinthelymphaticnetworkremains...

    • Chong Zhang, Lin Zhang, Tianlei Xu, Ruidong Xue, Liang Yu, Yuelu Zhu, Yunlong Wu, Qingqing Zhang, Do...
    • 2020
  5. 19 de set. de 2019 · Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The most common sites of metastasis are the liver and the peritoneum. Peritoneal carcinomatosis is often considered the end stage of the disease after the tumor has spread to the liver.

    • E. Pretzsch, F. Bösch, J. Neumann, P. Ganschow, A. Bazhin, M. Guba, J. Werner, M. Angele
    • 10.1155/2019/7407190
    • 2019
    • J Oncol. 2019; 2019: 7407190.
  6. 12 de nov. de 2021 · These promote the remodeling and SMC rearrangement of distant (post-SLN) lymphatic vessels and lymphangiogenesis in distant LNs and promote secondary metastasis, including organ metastasis, via the thoracic duct, which connects to the venous circulation via the subclavian vein.

  7. The invasion of lymphatic vessels by colorectal cancer (CRC) and its subsequent spread to draining lymph nodes is a key determinant of prognosis in this common and frequently fatal malignancy.