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23 de jun. de 2014 · Nucleotide excision repair (NER) eliminates structurally diverse DNA lesions by repairing helix-distorting damage throughout the genome as well as transcription-blocking lesions.
- Jurgen A. Marteijn, Hannes Lans, Wim Vermeulen, Jan H. J. Hoeijmakers
- 2014
14 de dez. de 2018 · Nucleotide excision repair is a conserved pathway to resolve bulky DNA adducts caused by different mutagens. XR-seq generates genome-wide repair maps of DNA damage across a range of organisms.
- Jinchuan Hu, Wentao Li, Ogun Adebali, Yanyan Yang, Onur Oztas, Christopher P. Selby, Aziz Sancar
- 2019
10 de set. de 2020 · The excision of genomic sequences using paired CRISPR-Cas nucleases is a powerful tool to study gene function, create disease models and holds promise for therapeutic gene editing.
- Hannah L Watry, Carissa M Feliciano, Ketrin Gjoni, Gou Takahashi, Yuichiro Miyaoka, Bruce R Conklin,...
- 2020
25 de mai. de 2022 · Nucleotide excision repair (NER) is a major pathway to deal with bulky adducts induced by various environmental toxins in all cellular organisms. The two sub-pathways of NER, global genome repair (GGR) and transcription-coupled repair (TCR), differ in the damage recognition modes.
- Xiping Zhang, Mengdie Yin, Jinchuan Hu
- 2022/06
- 10.3724/abbs.2022054
Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a barrier for DNA repair proteins to access DNA lesions buried in nucleosomal DNA.
- Katja Apelt, Hannes Lans, Orlando D. Schärer, Martijn S. Luijsterburg
- 2021
23 de mar. de 2022 · Nucleotide excision repair functions to protect genome integrity, and ongoing studies using excision repair sequencing (XR-seq) have contributed to our understanding of how cells prioritize repair across the genome.
8 de dez. de 2023 · In all cells—from bacteria to humans—nucleotide excision repair (NER) is a highly conserved, versatile DNA repair pathway that is responsible for the removal of a wide variety of DNA helix-distorting lesions arising from both endogenous and exogenous sources.
