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A dose response curve showing the normalised tissue response to stimulation by an agonist. Low doses are insufficient to generate a response, while high doses generate a maximal response. The steepest point of the curve corresponds with an EC 50 of 0.7 molar.
6 de ago. de 2018 · As intrinsic efficacy differs with drug structure, agonists can have different intrinsic efficacies and consequently be characterized as full or partial agonists. A full agonist typically produces the maximal response a system is capable of, whereas a partial agonist produces a submaximal response.
- Kelly A Berg, William P Clarke
- 10.1093/ijnp/pyy071
- 2018
- 2018/10
A hypothetical dose-response curve has features that vary (see figure Hypothetical Dose-Response Curve): Potency (location of curve along the dose axis) Maximal efficacy or ceiling effect (greatest attainable response) Slope (change in response per unit dose)
- Abimbola Farinde
1 de dez. de 2004 · Agonists bind to receptors to produce a functional response. Agonists can be full, partial or inverse. Antagonists reverse the effects of agonists. Antagonists can be competitive or non-competitive. Receptors.
- DG Lambert
- 2004
Dose–response curves of the agonist constructed in the presence of increasing doses of a competitive antagonist are progressively shifted to the right. Nevertheless, the effect of a reversible competitive antagonist can always be overcome by giving the agonist at a sufficiently high concentration (i.e. it is surmountable).
29 de jan. de 2009 · In this review I wish to consider methods for measuring affinity and efficacy at G protein coupled receptors (GPCRs). Agonist affinity may be estimated in terms of the dissociation constant for agonist binding to a receptor using ligand binding or functional assays.
An agonist is a drug that binds to a receptor and activates it, mimicking the effects of the body 's natural ligands. It can have a full or high efficacy on the receptor. A partial agonist also binds to a receptor but only partially activates it. It has lower efficacy than a full agonist.
