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George Herbert Hitchings (April 18, 1905 – February 27, 1998) was an American medical doctor who shared the 1988 Nobel Prize in Physiology or Medicine with Sir James Black and Gertrude Elion "for their discoveries of important principles for drug treatment", Hitchings specifically for his work on chemotherapy.
Bioquímica. George Herbert Hitchings ( Hoquiam, 18 de abril de 1905 — Chapel Hill, 27 de fevereiro de 1998) foi um bioquímico estadunidense . Foi agraciado com o Nobel de Fisiologia ou Medicina de 1988.
Hitchings propôs uma nova abordagem para a descoberta de medicamentos — racional e científica — com base no conhecimento de um alvo biológico. Ele levantou a hipótese de que os cientistas conseguiriam conter a replicação de células do patógeno com cópias defeituosas de seus alicerces genéticos.
George Hitchings (1905–1998) and Gertrude Elion (1918–1999) diverged from this traditional path by deliberately designing new molecules with specific molecular structures, using what today is termed rational drug design.
14 de abr. de 2024 · George Herbert Hitchings was an American pharmacologist who, along with Gertrude B. Elion and Sir James W. Black, received the Nobel Prize for Physiology or Medicine in 1988 for their development of drugs that became essential in the treatment of several major diseases.
- The Editors of Encyclopaedia Britannica
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26 de dez. de 2020 · George H. Hitchings and Gertrude B. Elion legacy—Professor Curt Peterson Professor Curt Peterson, Professor Emeritus in the Department of Biomedical and Clinical Sciences at Linköping University, Sweden, outlined the role of Gertrude Elion with George Hitchings in pioneering rational drug development.
