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Há 6 horas · Colorectal cancer is the leading cause of cancer death worldwide. The first and second lines of treatment for metastatic colorectal cancer (mCRC) include chemotherapy based on 5-fluorouracil. However, treatment following progression on the first and second line is still unclear. We searched PubMed, Scopus, Cochrane, and Web of Science databases for studies investigating the use of trifluridine ...
Há 6 horas · Men with metastatic colorectal cancer with an unfavorable mGPS of 1 to 2 benefit from upfront intensive combination therapy versus less intensive sequential chemotherapy. Women with a favorable mGPS of 0 may benefit from less intensive treatment, reaching comparable survival with less toxicity. mGPS might serve as a new tool for choosing gender-specific treatment intensity but warrants ...
Há 6 horas · Multiple studies on prostate, colorectal, and pancreatic cancer have shown that CAFs secrete factors such as CXCL12 and IL-6 that increase M2 macrophage recruitment and polarization (Fig. 3 ...
Há 6 horas · Exploring the Efficacy of Targeted Therapies in Colorectal and Upper GI Cancers: An Analysis of Recent StudiesThe field of oncology has witnessed significant advancements in recent years, with targeted therapies playing a pivotal role in improving patient outcomes. In this article, we will discuss two key studies conducted by Gilead Sciences, Inc. and Arcus Biosciences, Inc., highlighting the ...
Há 6 horas · Background Studies have shown that oxidative stress and its resistance plays important roles in the process of tumor metastasis, and mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) damage is an important molecular event in oxidative stress. In lung cancer, the normal fibroblasts (NFs) are activated as cancer-associated fibroblasts (CAFs), and act in the realms of the tumor ...
Há 6 horas · The FRUTIGA trial results published by Nature Medicine suggest that fruquintinib could be another effective treatment option for gastric cancer patients. FRUTIGA was a 1:1 randomized, double-blind, Phase III study conducted across 35 sites in China ( NCT03223376 ). It evaluated fruquintinib in combination with paclitaxel chemotherapy, compared ...
Há 4 horas · For the first-line treatment of unresectable locally advanced or metastatic squamous non-small cell lung cancer; For the first-line treatment of unresectable or metastatic hepatocellular carcinoma ...
