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Há 10 horas · We investigated the genetic and epigenetic interplay in hypertension using whole-genome bisulfite sequencing. Methylation profiling in 918 males revealed allele-specific methylation and methylation quantitative trait loci. We engineered rs1275988 T/C mutant mice using CRISPR/Cas9, bred them for homozygosity, and subjected them to a high-salt diet.
Há 10 horas · Next, we performed PPP1R15A silencing in AML cell lines in two separate experiments using siRNA and CRISPR-cas9, respectively. Our findings highlight that DDR regulators demonstrate increased expression in patients with high cytogenetic risk possibly reflecting increased genotoxic stress.
Há 10 horas · The knockout mutants of OsMADS56 were generated by CRISPR/Cas9 system, and OsMADS56 overexpressing lines were driven by Ubiquitin promoter. The osmads56 mutant in Zhonghua11 (ZH11) background was purchased from the WIMI Biotechnology Co., Ltd (Changzhou, China) (Lu et al., 2017).
Há 10 horas · The identified sex-determining gene locus was also detected in several closely related green toad species. In the next step, the researchers want to validate their result using the CRISPR/Cas9 technique by specifically controlling the expression of the identified gene bod1I.
Há 5 horas · But ultimately I think we've shown remarkable data with our CRISPR/Cas9 editing with these ex vivo cells. We've done this together with our partner Vertex. The relationship we have with Vertex is ...
Há 10 horas · 2) Page 8: lines 316-321: “in the same study, DNA- and RNA-sequencing coupled with flow cytometry of CRISPR/Cas9 engineered AEL tumor models, have demonstrated that the primary clone consists mostly of immature hematopoietic cells expressing erythroid/lymphoid markers and of progenitor erythroid cells expressing GATA1, whereas more differentiated erythroid cells expressing hemoglobin genes ...
Há 10 horas · Furthermore, the application of CRISPR-Cas9 gene-editing technology induced mutations which seemed to enhance curiosity in the fish, thus altering their exploratory behavior. This genetic variant mirrored in humans has associations with schizophrenia and bipolar disorders, adding a fascinating layer to the study.
