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Há 9 horas · Immunotherapy is more effective than chemo on this specific type of colorectal cancer because it contains a high number of DNA errors, the medical oncologist explained. “That means that the tumor cells are more easily detected by the immune system. The immune system only requires a small incentive to successfully target the tumor cells.”.
Há 9 horas · Purpose of Review The use of circulating tumor DNA (ctDNA) assays to guide clinical decision-making in early-stage colon cancer is an area of rapidly advancing active research. With assays clinically available, clinicians must be informed how to best use this novel tool to treat patients. Recent Findings Recent observational and prospective studies have suggested that ctDNA has potential to ...
Há 9 horas · KDM6A (lysine demethylase 6A) has been reported to undergo inactivating mutations in colorectal cancer, but its function in the progression of colorectal cancer has not been evaluated using animal models of colorectal cancer. In this study, we found that knocking out KDM6A expression in mouse intestinal epithelium increased the length of villus and crypt, promoting the development of AOM ...
Há 9 horas · Serrated polyps (SPs) are precursors to 15–20% of colorectal cancers (CRCs). However, there are uncertainties regarding which SPs require surveillance and at what intervals, with recommendations adapted from those for adenomas in the absence of solid evidence. Our aim was to assess which SP risk characteristics relate to a higher risk of metachronous CRC or advanced polyps.
Há 9 horas · Progressed colorectal cancers are known to be highly fatal because of their high metastatic potential. They comprise a complex tumor fine environment consisting of various cancer-associated cells, and can become malignant in a short time through various growth factors [ 1 ].
Há 9 horas · Bowel cancer, or colorectal cancer (CRC), is the third most commonly diagnosed cancer in Australia, affecting thousands each year. Its association with lifestyle factors such as physical inactivity, obesity, and poor dietary habits underscores the importance of integrated health approaches in its management and prevention.
Há 9 horas · The announcement comes as the first patient in England was treated with a personalised vaccine against bowel cancer, after an agreement with the German biotechnology company BioNTech to provide as many as 10 000 patients with precision cancer immunotherapies by 2030.
