Resultado da Busca
Infobox references. Catechol ( / ˈkætɪtʃɒl / or / ˈkætɪkɒl / ), also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula C6H4(OH)2. It is the ortho isomer of the three isomeric benzenediols. This colorless compound occurs naturally in trace amounts.
兒茶酚-O-甲基轉移酶 （ COMT; EC 2.1.1.6 ）是分解 兒茶酚胺 （如 多巴胺 、 腎上腺素 和 去甲腎上腺素 ）的幾種酶之一。. 在人體， 兒茶酚-O-甲基轉移酶 由 COMT 基因 編碼 [2] 。. 鑒於在一些疾病中兒茶酚胺的調節受損，數種藥物以 COMT 為標靶，調整其活性來控制 ...
Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. Although its classical function has been established for more than five decades, a …
COMT catalyzes O-methylation of 2-OHE2/E1 at the 2-OH and 3-OH positions and of 4-OHE2/E1 at the 4-OH position with the methyl group derived from S-adenosylmethionine. The catechol metabolites of E2 and E1, particularly 4-OH E2/E1, have been shown to be carcinogenic [ 8 , 9 ].
7 de abr. de 2020 · 1. Introduction. The mammalian catechol-O-methyltransferases (COMT, EC 2.1.1.6) are an important class of conjugative enzymes that catalyze O-methylation of catechol substrates, transferring the methyl of S-adenosyl-l-methionine (SAM) to one of hydroxyl groups of catechol substrates in the presence of Mg 2+ (Fig. 1) [, , ].
Catecholamines are short acting bioactive compounds with a very short half-life of 1–2 min (Fung et al. 2008). Among other functions, they generically promote vasoconstriction, sphincter contraction, hepatic glycogenolysis and have ionotropic and chronotropic effects in the heart (Guimaraes and Moura 2001). ~.
21 de fev. de 2014 · Abstract. Catechol-O-methyltransferase (COMT) is of great importance in pharmacology because it catalyzes the metabolism (methylation) of endogenous and xenobiotic catechols. Moreover, inhibition of COMT is the drug target in the management of central nervous system (CNS) disorders such as Parkinson's disease due to its role in regulation of ...
